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Molecular Devices Life Science Applications

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A Cardiovascular Disease Linked Gut Microbial Metabolite

Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (n = 4,000 subjects) to be associated with cardiovascular disease (CVD) and incident major adverse cardiovascular events (myocardial infarction, stroke, or death).A gut microbiota derived metabolite, PAGln, was

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